Last edited by Doucage
Tuesday, May 12, 2020 | History

3 edition of Chemical proteomics found in the catalog.

Chemical proteomics

Gerard Drewes

Chemical proteomics

methods and protocols

by Gerard Drewes

  • 260 Want to read
  • 40 Currently reading

Published by Humana Press in New York .
Written in English

    Subjects:
  • Analytical Chemistry Techniques,
  • Methods,
  • Biochemistry,
  • Proteomics,
  • Laboratory manuals,
  • Laboratory Manuals

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Gerard Drews and Marcus Bantscheff
    SeriesMethods in Molecular Biology -- 803, Springer protocols, Methods in molecular biology (Clifton, N.J.) -- v. 803., Springer protocols
    Classifications
    LC ClassificationsQP551 .C516 2012, QH506 .M45 v.803
    The Physical Object
    Paginationxi, 313 p. :
    Number of Pages313
    ID Numbers
    Open LibraryOL25298838M
    ISBN 101617793639
    ISBN 109781617793639
    LC Control Number2011937567
    OCLC/WorldCa733249534

    Our proteomics research books gives scientists a variety of resources on the dynamic nature of gene expression and regulation with protein profiling. With its detailed description of membrane protein expression, high-throughput and genomic-scale expression studies, both on the analytical and.   Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and by: 4.

    chemical ionization, field desorption, field ionization, plasma desorp- This book, Introduction to Proteomics: Tools for the New Biology by Pro-fessor Daniel Liebler, presents a tutorial on mass spectrometry and its use in proteomics. The basics of mass spectrometers and ionization Introduction to Proteomics: File Size: 3MB. Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics.

    The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. Chemical proteomics is now widely applied to identify possible targets of kinase inhibitors through affinity purification from cellular extracts, resulting in the identification of the whole spectrum of potential drug targets and providing a strong foundation for developing novel potent drugs that exert no side by:


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Chemical proteomics by Gerard Drewes Download PDF EPUB FB2

In Chemical Proteomics: Methods and Protocols, expert researchers in the field provide key techniques to investigate chemical proteomics focusing on analytical strategies, how probes are generated, techniques for the discovery of small molecule targets and the probing of target function, and small molecule ligand and drug : Hardcover.

About this book The multidisciplinary science of chemical proteomics studies how small molecules of synthetic or natural origin bind to proteins and modulate their function.

In Chemical Proteomics: Methods and Protocols, Chemical proteomics book researchers in the field provide key techniques to investigate chemical proteomics focusing on analytical strategies, how probes are generated, techniques for the discovery of small molecule targets and the probing of target function, and small molecule ligand and drug discovery.

Emphasizing mass spectrometry, this book provides strategies and concepts for understanding and analyzing chemical proteomics, their functions, modifications, and interactions.

Chapters cover technical advances and applications in drug discovery, from. Covering mass spectrometry for chemical proteomics, this book helps readers Chemical proteomics book analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery.

About this book Introduction The multidisciplinary science of chemical proteomics studies how small molecules of synthetic or natural origin bind to proteins and modulate their function.

About this book Introduction Chemical genomics technology has been steadily improving, delivering new biological probes and drugs, and the explicit use of the term ‘chemical proteomics’ has increased with it, as proteins have always been at the heart of this technology.

Artemisinins are the most potent and safe antimalarials available. Despite their clinical potential, no human target for the artemisinins is known. The unbiased interrogation of several human cDNA libraries, displayed on bacteriophage T7, revealed a single human target of artesunate; the intrinsically disordered Bcl-2 antagonist of cell death promoter (BAD).Cited by: 3.

Chemical Proteomics Chemical proteomics includes a powerful set of complementary, mass spectrometry based and proteome-wide approaches for identifying the key proteins relevant for producing the phenotypic effects of a treatment, including direct and indirect interactions with as well as mechanism of action.

Chemical proteomics is a growing area of chemical biology that seeks to design small molecule probes to understand protein function.

In the context of natural products, chemical proteomics can be used to identify the protein binding partners or targets of small molecules in live by: PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and.

Activity-Based Probe Design. The small molecules used in chemical proteomics, so-called activity-based probes (ABPs), generally consist of three basic elements ().The warhead consists of a reactive functional group that is able to covalently attach to the active site of an enzyme, while the tag can be used for identification and purification of modified by: The Chemical Proteomics facility (ChemProt) is a recent national facility expert on supporting drug discovery and development by proteome-wide deconvolution of targets and mechanism of action (MoA) of small molecules or any active compounds.

PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind Author: W.

Andy Tao. Chemical Genomics and Proteomics - CRC Press Book Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics.

Proteomics provides an introductory insight on proteomics, discussing the basic principles of the field, how to apply specific technologies and instrumentation, and example applications in human health and diseases. With helpful study questions, this textbook presents an easy to grasp and solid overview and understanding of the principles, guidelines, and especially the complex instrumentation.

Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.

Chemical genomics technology has been steadily improving, delivering new biological probes and drugs, and the explicit use of the term ‘chemical proteomics’ has increased with it, as proteins have always been at the heart of this technology.

In Chemical Genomics and Proteomics: Reviews and. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses.

The next section covers a variety of techniques and strategies coupling chemical probes DOWNLOAD BOOK. Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics.

This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that Format: Hardcover. Chemical Proteomics. In book: Plant Proteomics: Technologies, Strategies, and Applications, pp - 59 minor chemical variation of the ligand by immobilizing the closely related.Proteomic profiling using bioorthogonal chemical probes that selectively react with certain amino acids is now a widely used method in life sciences to investigate enzymatic activities, study posttranslational modifications and discover novel covalent inhibitors.

Over the past two decades, researchers have dCited by: 4.Book Description. Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics.

This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the.